Childhood Liver Disease Research Network (ChiLDReN): A Prospective Database of Infants With Cholestasis
Arbor Research Collaborative for Health
Summary
Biliary atresia, idiopathic neonatal hepatitis, and specific genetic cholestatic conditions are the most common causes of jaundice and hyperbilirubinemia that continue beyond the newborn period. The long term goal of the Childhood Liver Disease Research Network (ChiLDReN) is to establish a database of clinical information and plasma, serum, and tissue samples from cholestatic children to facilitate research and to perform clinical, epidemiological and therapeutic trials in these important pediatric liver diseases.
Description
This is a multi-center project to establish a prospective database of clinical information and a repository of blood, from children with diagnosis of neonatal liver disease, such as biliary atresia (BA), in order to perform research in this important liver problem. Children (diagnosed with BA or suspicious for BA) will be screened and enrolled at presentation at the participating pediatric liver sites. Participants diagnosed with BA will be followed intensively for the first year, at 18 months of age, and then annually up to 10 years of age, and then biannually, or liver transplantation. Other…
Eligibility
- Age range
- Up to 0 years
- Sex
- All
- Healthy volunteers
- No
INCLUSION CRITERIA * Infant's age less than or equal to 180 days at initial presentation at the ChiLDReN clinical site. * Diagnosis of cholestasis defined by serum direct or conjugated bilirubin greater than or equal to 2 mg/dl and suspected biliary atresia. * The subject's parent(s)/guardian(s) willing to provide informed written consent. EXCLUSION CRITERIA * Acute liver failure. * Previous hepatobiliary surgery with dissection or excision of biliary tissue. * Diagnoses of bacterial or fungal sepsis (except where associated with metabolic liver disease) * Diagnoses of hypoxia, shock or isc…
Locations (16)
- Children's Hospital Los AngelesLos Angeles, California
- University of CaliforniaSan Francisco, California
- Children's Hospital ColoradoAurora, Colorado
- Children's Healthcare of Atlanta - Emory UniversityAtlanta, Georgia
- Ann & Robert H. Lurie Children's Hospital of ChicagoChicago, Illinois
- Riley Hospital for ChildrenIndianapolis, Indiana