Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
UConn Health
Summary
The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in the research laboratory. Thus, the purpose of this study is to determine the relation between the change of these two proteins in the blood and the occurrence of acute heart failure. At this time, detection of an increase in these proteins in the blood is not known to be associated with any disease or heart failure.
Description
Heart failure (HF) is a complex clinical syndrome and major public health problem claiming the lives of \>500,000 per year. It is the leading Diagnosis Related Group (DRG) for hospital discharges in the US. There are approximately 1-3 million admissions annually for acute decompensated heart failure. The mortality rate in Classes III and IV heart failure is 14-18% each year (1). At present, nearly 5 million patients have HF in the U.S. (2). Early detection and prevention remain key measures in treating subjects with this form of heart disease. Discovering and defining circulating markers that…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Individuals aged \>18yrs * stable or decompensated heart failure, irrespective of LVEF * decompensated heart failure clinical symptoms such as dyspnea, rales, edema, elevated jugular venous pressure, or ascites * Imaging evidence of heart failure (cardiomegaly, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures) * Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls. Exclusion Criteria: * Subjects who are unable to give inf…
Location
- University of Connecticut Health CenterFarmington, Connecticut