Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas
University of Michigan Rogel Cancer Center
Summary
Colon cancer is the second most common cancer in men and women. It is a disease that can be prevented if it is found early. Colonoscopy is still the best screening tool for colon cancer and the polyps that turn into colon cancer. However, due to a variety of factors, including affordability, time, and age, not all patients are able to be screened. Researchers are working on other options for early detection that are as accurate as colonoscopy. The purpose of this study if to determine if stool or blood can be used to detect colon cancers as early or earlier than colonoscopy. The researchers plan to use these samples to learn about specific proteins (also known as biomarkers) that may indicate colon polyps, colon cancer or an increased risk of developing colon cancer. In order to learn more about preventing and detecting colon and rectal cancer, we are collecting samples from subjects with cancer, adenomas, and colonoscopies who may be at risk for polyps.
Description
In recognition of the fact that novel potential biomarkers are continually being identified and will need to be validated in a rapid, efficient and scientifically rigorous manner, the NCI has made an enormous commitment to the development of a network that will facilitate biomarker development and validation in multiple organ sites. As part of the National Cancer Institute-funded Early Detection Research Network (EDRN), the Great Lakes-New England Clinical Epidemiological Center (GLNE CEC) proposes a research study that validates potential molecular markers ("biomarkers") for the detection of…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Willing to sign informed consent * Able to physically tolerate removal of up to 60 ml of blood * Adults at least 18 years old * Willing to collect 1-2 stool samples and prepare a Fecal Immunochemical Test (FIT) * Pregnant or nursing women who otherwise meet the eligibility criteria may participate * Subjects with one of the following: * Colorectal adenocarcinoma-not treated and in colon at time of stool collection (CRC bin) * Adenoma-pathologically confirmed adenoma present in colon at time of stool collection (Adenoma Bin) * Higher Risk Non-neoplastic Bin *…
Locations (13)
- Cedars-Sinai Medical CenterLos Angeles, California
- Carle Cancer CenterUrbana, Illinois
- Dana Farber Cancer InstituteBoston, Massachusetts
- University of MichiganAnn Arbor, Michigan
- University of MinnesotaMinneapolis, Minnesota
- NYU Langone HealthNew York, New York