Study of Biomarkers in Solid Organ and Bone Marrow Transplant Recipients to Better Treat Rejection
University of Pittsburgh
Summary
The objective of this study is to evaluate whether certain proteins, expressed in biological tissues can indict a better understanding of the effect of drugs that are used to treat rejection, and of processes leading to rejection and rejection-free outcomes.
Description
All transplant recipients receive periodic monitoring of drug levels and laboratory tests to assess adequacy of immunosuppression and allograft function. These are performed when the recipient is admitted to the hospital after transplantation or for a complication such as acute rejection or toxicity, or when the recipient is an outpatient. 1. Blood samples: Participants may be asked to provide research blood specimens during regular clinical tests, and may collect up to 15 milliliters of blood as many as 7 times within the first year of transplant, and then less often thereafter. The total vo…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Recipients of abdominal, thoracic and bone marrow allografts that are receiving inpatient and outpatient follow-up with routine laboratory tests at the University of Pittsburgh Medical Center. * All Ages * Subject or parents are able to read and understand the informed consent Exclusion Criteria: * Subjects and/or their parents who are unable to read and understand informed consent.
Location
- Children's Hospital of Pittsburgh of UPMCPittsburgh, Pennsylvania