Celiac Disease Genomic Environmental Microbiome and Metabolomic (CDGEMM) Study
Massachusetts General Hospital
Summary
Celiac disease (CD) is a complex disease caused by eating gluten, a protein contained in wheat, rye, and barley. It is well known that many factors contribute to the development of CD, including the genes that you have and the foods that you eat. In the CDGEMM study, we will consider as many of these factors as possible and study how they each contribute to disease development. If the investigators find that any one factor, or combination of factors, increases the risk of developing CD, we will be able to apply this information and help prevent or detect disease in high-risk children in the future.
Description
The CDGEMM study will address genomic, environmental, microbiome, and metabolomic factors that could affect the development of CD. Genomic: The investigators will study children who have a first degree relative with celiac disease so that we can understand how their genes may contribute to whether they develop CD or not. Scientists and doctors are already aware of one group of genes, called the HLA DQ2 and DQ8 genes, which are involved in the development of CD. These genes are necessary for development of CD, but cannot alone predict who will develop the disease. The investigators hope that t…
Eligibility
- Age range
- Up to 0 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Newborns and infants less than 6 months of age who have not been introduced to solid foods (exclusive breast milk or formula diet) * First-degree relatives of patients affected with biopsy-proven CD Exclusion Criteria: * Infants older than 6 months of age * Inability or unwillingness of legal guardian/representative to give written informed consent
Locations (2)
- MassGeneral Hospital for ChildrenBoston, Massachusetts
- University of Roma La SapienzaRome