Metabolic Biomarkers in Thoracic Cancers
University of Texas Southwestern Medical Center
Summary
The purpose of this research study is to develop a method of using magnetic resonance imaging (MRI) to evaluate lung tumors and other thoracic malignancies. An MRI is a scanning device that uses magnets to make images (pictures) of the body. This study is being done to determine what series of reactions (metabolic pathways) pulmonary nodules use as they burn sugar as fuel for growth. The manner in which the tumor burns (metabolizes) sugar for fuel is being investigated by using a natural, slightly modified, sugar solution (13C-glucose) and studying a small sample of the tumor once it is removed at the time of surgery.
Description
The recent report of the findings of the National Lung Screening Trial indicates that screening a high-risk population using low dose CT results in a 20% reduction in lung cancer mortality. At our institution, some of positive nodules that are 1 cm or larger would be imaged using combined fluoro-deoxyglucose positron emission tomography (FDG PET)/CT. Highly suspicious nodules would be biopsied if the risks were manageable. Otherwise, the suspicious nodules not eligible for biopsy and so-called "indeterminate" nodules are followed using CT to be evaluated for interval growth. The overall goal…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Patients must have known or probable malignant lesions requiring surgical biopsy or excision. 2. Subjects of all races and ethnic origins over 18 years of age. Exclusion Criteria: 1. Not a surgical candidate. 2. Poorly controlled diabetes.
Interventions
- ProcedureImaging Biomarkers
Want to see if using 13C-glucose helps in detecting cancer and deciding on a treatment plan.
Location
- University of Texas Southwestern Medical CenterDallas, Texas