PET Imaging of Hepatocellular Carcinoma With 18F-FSPG
M.D. Anderson Cancer Center
Summary
This clinical trial studies fluorine F 18 L-glutamate derivative BAY94-9392 (18F-FSPG) positron emission tomography (PET) in imaging patients with liver cancer before undergoing surgery or transplant. Diagnostic procedures, such as 18F-FSPG PET, may help find and diagnose liver cancer and find out how far the disease has spread.
Description
PRIMARY OBJECTIVES: I. To evaluate the relationship between 18F-FSPG PET/computed tomography (CT), pathology, and cancer metabolism in patients with suspected hepatocellular carcinoma (HCC) scheduled for liver resection surgery and orthotopic liver transplant (OLT). II. To compare 18F-FSPG PET/CT with standard-of-care (SOC) diagnostic MRI imaging in patients with suspected HCC scheduled for liver resection surgery or OLT. III. To compare the uptake of 18F-FSPG PET/CT with 11C-acetate PET/CT AND 18F-FDG PET/CT in suspected HCC and background liver in patients scheduled for liver resection su…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Diagnosis of HCC with one or more of the following: 1. Liver mass with non-rim arterial phase hyperenhancement (APHE) and one of the following: 1) 10-19 mm with ≥2 additional major features according to LI-RADS criteria ("washout", enhancing "capsule", and/or threshold growth), 2) 10-19 mm with "washout" and visibility at antecedent ultrasound (US) but with no "capsule" or threshold growth, 3) 10-19 mm with ≥50% size increase in ≤6 months but with no "washout" or "capsule" or 4) ≥20 mm with ≥1 additional major feature according to LI-RADS criteria ("washout", enhanc…
Interventions
- BiologicalFluorine F 18 L-glutamate Derivative 18F-FSPG
Undergo 18F-FSPG PET scan
- BiologicalCarbon C 11 Acetate
Undergo 11C-acetate PET scan
- ProcedurePositron Emission Tomography
Undergo 18F-FSPG, 11C-acetate, or 18F-FDG PET
- OtherLaboratory Biomarker Analysis
Correlative studies
- BiologicalFluorine F 18 2-deoxy-2-(18F)fluoro-D-glucose
Undergo 18F-FDG PET scan
Location
- MD Anderson Cancer CenterHouston, Texas