MRI Technical Development and Applications in Kidney Disease
University of Minnesota
Summary
Magnetic resonance imaging (MRI), as a non-invasive and non-contrast enhanced technique, has the potential to improve patient health care and management. The overall objective of proposed project is to: 1. develop, customize, and optimize anatomic and functional MRI methods, 2. explore the use of MRI methods to study CKD and evaluate post-transplant kidneys, and 3. investigate the potential of MRI in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction. In addition to direct studies of the kidney, brain MRI studies will also be performed to identify the cerebrovascular and cognitive effects of chronic renal function deficiency and medical treatment (e.g. hemodialysis and immunosuppression). The brain and kidneys have similar vascular bed, and both are susceptible to vascular injury, which provides the pathological basis for the widely recognized association of reduced renal function with prevalent cerebrovascular diseases (CVDs) and cognitive impairment (CI). The MRI methods in the brain will be applied to explore the origins for widely observed CVDs and prevalent cognitive impairment (CI) in kidney disease patients.
Description
Specific Aims The overall objective is to develop and validate MRI methods for the evaluation and monitoring of renal status and associated cerebrovascular effects of renal dysfunction and treatment. The proposed project include two phases: 1) MRI technical development and validation with reproducibility studies; 2) clinical pilot studies with two patient populations (CKD patients and renal transplant recipients) to explore the potential of MRI in evaluating CKD, post-transplantation renal dysfunction and cerebrovascular pathophysiology associated with or induced by reduced kidney function an…
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- Yes
For Specific Aim 1: MRI Technical Development Studies Inclusion Criteria: 1\. Healthy Volunteer Exclusion Criteria: 1. Ferromagnetic implants 2. Any foreign metal objects in the body 3. History of shrapnel or shot gun injury 4. Cardiac pacemakers 5. Defibrillator 6. Neuronal stimulator 7. Magnetic aneurysm clip 8. Large tattoos on the abdomen or the brain and neck 9. Hip replacement 10. Too large to fit in the magnet (body mass index \>= 40, approx.) 11. Severe claustrophobia 12. Women with pregnancy For Specific Aim 2: Pilot Studies with Patients Studies for CKD Inclusion 1. English-…
Location
- Center for Magnetic Resonance ResearchMinneapolis, Minnesota