Early Detection of Inflammatory Biomarkers in Infection
Beth Israel Deaconess Medical Center
Summary
The purpose of this investigation is to evaluate how early biomarkers of infection and inflammation perform in identifying patients at risk for poor outcome in sepsis and septic shock.
Description
The body's immune system and a subsequent inflammatory response are triggered during infection. The detection of an activated immune system, and an indication of the degree of the host response, is helpful to the clinician both in assessing the severity of infection and in patient treatment and management. Currently, the white blood cell count and the differential are the most common laboratory parameters for measuring host response. The sedimentation rate and CRP are also used to detect inflammation. However, these tests are all imperfect predictors, and a test providing a better assessment o…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria for Infected subjects: * Age 18 years of age or older * Confirmed or suspected infection Inclusion Criteria for Control Subjects: * Age 18 years of age or older * A non-infectious clinical presentation to include * Normal white blood cell count ( \> 4,000 and/or \< 12,000) * Normothermia ( \> 96.5 and/or less 100.4) * Absence of the following clinical complaints: productive cough, fever, pyuria, rash * No evidence of acute coronary syndrome Exclusion Criteria for Control Subjects: \- Suspected infection
Locations (2)
- Massachusetts General HospitalBoston, Massachusetts
- Beth Israel Deaconess Medical CenterBoston, Massachusetts