Phase II Trial of Salvage Radiation Therapy to Induce Systemic Disease Regression After Progression on Systemic Immunotherapy
M.D. Anderson Cancer Center
Summary
This phase II trial studies the side effects and best dose of radiation therapy and to see how well it works in treating patients with cancer that has spread to other places in the body (metastatic) or has increased in size after being treated with immunotherapy. Giving radiation therapy may help to control the cancer after the disease has gotten worse after receiving immunotherapy in patients with cancer that has spread to the other places in the body.
Description
PRIMARY OBJECTIVES: I. To identify immunotherapy-based treatments where salvage radiation produces systemic disease control after initial progressive disease. II. To identify immunotherapy-based treatments where salvage radiation produces a high rate of treatment-related toxicities. SECONDARY OBJECTIVES: I. To determine the frequency of systemic disease control (objective response or stable disease) after salvage radiation following progression on immunotherapy among all patients and within each treatment group. II. Determine the frequency of dose limiting toxicities (DLTs) with salvage r…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Pathologically confirmed diagnosis of cancer. 2. Progressive disease via irRC on prior study or standard of care therapy utilizing an immunotherapy agent OR a clinical status that requires salvage radiation treatment (e.g.: palliative RT) at the discretion of treating Physician and/or PI. 3. Previous progression of disease while on treatment of an immunotherapy agent or cell-based therapy. a. Patients may continue with maintenance immunotherapy as part of standard of care therapy while receiving radiation. 4. Have at least one site of metastatic disease amenable to…
Interventions
- RadiationExternal Beam Radiation Therapy
Undergo EBRT
- OtherLaboratory Biomarker Analysis
Correlative studies
- RadiationStereotactic Body Radiation Therapy
Undergo SBRT
Locations (5)
- MD Anderson in The WoodlandsConroe, Texas
- M D Anderson Cancer CenterHouston, Texas
- MD Anderson West HoustonHouston, Texas
- MD Anderson League CityLeague City, Texas
- MD Anderson in Sugar LandSugar Land, Texas