Imaging SV2A in Mood Disorders
Yale University
Summary
This study is designed to examine SV2A density in MDD and PTSD as a correlate of synaptic density, and to determine whether ketamine administration will reverse the synaptic loss in vivo in human subjects. To our knowledge, this is the first human study to examine SV2A in vivo in MDD and PTSD and to use the first known drug (ketamine) that rapidly reverses synaptic loss to determine whether ketamine administration could restore some of the structural changes associated with depression and PTSD. After a screening process to determine eligibility, all subjects will participate in an MRI, and 2-3 PET scans with the administration of ketamine for one of the scans. Cognitive testing and a stress test may also be done on scan days.
Description
The goal of the study is to determine whether there are alterations in synaptic vesicle glycoprotein 2A (SV2A), a protein expressed ubiquitously in synaptic vesicles, in depression and anxiety and whether ketamine, an N-Methyl-D-aspartate (NMDA) antagonist, normalizes SV2A density at time of its greatest anti-depressant response. This study will conduct an examination of SV2A and associated consequences using neuroreceptor imaging and behavioral techniques for the following aims. Aim 1: To compare SV2A availability in individuals with MDD, healthy control individuals, bipolar individuals, and…
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * General inclusion criteria: 1. Subjects will be 18-70 years old, 2. English speaking, 3. No other DSM-5 diagnosis present, besides required as below. Inclusion criteria for depressed subjects: 1. Meet DSM-5 diagnostic criteria for Major Depressive Disorder, and for a current depressive episode. 2. Treatment or non-treatment seeking who understand that this study is for research purposes only. Inclusion criteria for healthy controls: 1\. No current, or history of any DSM-5 diagnosis. Inclusion criteria for PTSD subjects: 1\. Current Post Traumatic Stress Diso…
Interventions
- DrugKetamine
Ketamine will be administered after the initial PET scan for subjects participating in the ketamine aim.
Location
- PET CenterNew Haven, Connecticut