Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation, a Multicenter Study
University of Alberta
Summary
INTERLIVER is a prospective observational study of the relationship of the molecular phenotype of 300 liver transplant biopsies to the histologic phenotype and the clinical features and outcomes. A segment of a biopsy performed as standard-of-care for indications, or by center protocol, will be used for gene expression study.
Description
The current standard for biopsy-based diagnoses of dysfunction of liver transplants is histology (the Banff system), an arbitrary international empirical consensus based on lesions and rules, similar in principle to the kidney, heart, and lung histology systems. Recent data-driven approaches using molecular and conventional technologies indicate that such systems frequently produce incorrect diagnoses - perhaps 40-50% in abnormal kidney or heart transplant biopsies and even more in lung biopsies, with great potential for harm to patients due to inappropriate treatment. To address this unmet n…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * biopsy for clinical indications Exclusion Criteria: * no consent, pregnant women
Interventions
- Procedureliver biopsy
5 mm fragment of liver transplant biopsy taken for clinical indication
Locations (15)
- University of California San Francisco, Transplant Research UnitSan Francisco, California
- Northwestern Memorial HospitalChicago, Illinois
- University of Maryland School of MedicineBaltimore, Maryland
- Henry Ford Transplant InstituteDetroit, Michigan
- Vanderbilt University Medical Center, Vanderbilt Transplant CenterNashville, Tennessee
- Baylor University Medical Center, Annette C. and Harold C. Simmons Transplant InstituteDallas, Texas