Beating Lung Cancer in Ohio (BLCIO) Protocol
Ohio State University Comprehensive Cancer Center
Summary
This randomized clinical trial studies the Beating Lung Cancer in Ohio protocol in improving survival in patients with stage IV non-small cell lung cancer. The Beating Lung Cancer in Ohio protocol may help in evaluating immunotherapies and targeted therapies that prolong survival, have more favorable toxicity profiles than conventional chemotherapy and impact quality of life.
Description
PRIMARY OBJECTIVES: 1a. Establish a 3 month observation period for newly diagnosed stage IV non-small cell lung cancer patients (NSCLC)(n=300), using the statewide research network, documenting usual care (UC) practices, survival and quality of life and patients previously diagnosed with stage IV NSCLC within one year prior to initiating the study, (n=300). 1b. Establish a cohort of newly diagnosed stage IV non-small cell lung cancer patients (NSCLC), documenting usual care (UC) practices, survival and quality of life and patients previously diagnosed with stage IV NSCLC within one year prio…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * AIM 1-3 * Pathologically confirmed stage IV NSCLC (with any Eastern Cooperative Oncology Group \[ECOG\] performance status, and any NSCLC - adenocarcinoma, squamous cell, etc.) with available imaging OR patients who do not yet have their staging completed, but in the judgment of the physician are likely to be stage IV; * Patients may be enrolled if the recruiter cannot reach the patient by the first office visit, preferably prior to starting therapy and no later than one month after starting therapy; (NCCN guidelines allow for a switch to targeted therapy from chemoth…
Interventions
- OtherBest Practice
Receive usual care
- ProcedureBiospecimen Collection
Undergo collection of tumor tissue and blood sample for repository
- ProcedureBiospecimen Collection
Undergo tumor tissue and blood sample for AGIT/DS
- OtherLaboratory Biomarker Analysis
Correlative studies
- OtherMedical Chart Review
Undergo medical record abstraction
- OtherQuality-of-Life Assessment
Ancillary studies
- OtherQuestionnaire Administration
Location
- Ohio State University Comprehensive Cancer CenterColumbus, Ohio