Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane
Baylor College of Medicine
Summary
The purpose of this protocol is to determine the effect of two clinically applicable Dexmedetomidine dosages (0.5mcg/kg and 1mcg/kg) on the minimum alveolar concentration (MAC) of Sevoflurane in children between the age ranges of: 1-6 months; 6-12 months of age and 12 months-36 months years of age.
Description
The anesthetic potency of an inhalational anesthetic is measured by the minimum alveolar concentration (MAC), or the dose required to suppress movement to a surgical stimulus in 50% of patients. This measure of potency may also be used to assess the effects of other agents on the MAC of the inhalational agent. Sedative agents reduce MAC of inhalational anesthetic agents. Two human adult studies have shown that Dexmetomidine decreased the minimum alveolar concentration of Isoflurane and Sevoflurane. Age has an important effect on the MAC of inhalational anesthetics in children. Sevoflurane is a…
Eligibility
- Age range
- 0–3 years
- Sex
- All
- Healthy volunteers
- Yes
Exclusion Criteria: 1. Interstitial lung disease, chest wall disease, or bronchospastic disease with no flare-ups in the past 2 weeks of presentation 2. History of difficult intubation or ventilation 3. Airway malformation 4. Congenital heart disease 5. Cardiac arrhythmias 6. Central nervous system disease, including developmental delay, cerebral palsy, or seizure disorder 7. History of or family history of malignant hyperthermia 8. Electrolyte disorders 9. Gastrointestinal disease 10. Hepatic dysfunction 11. Renal dysfunction 12. Metabolic disease, such as diabetes 13. Obesity, defined as a…
Interventions
- DrugDexmedetomidine
Dexmedetomidine 9 arms
Location
- Texas Children's HospitalHouston, Texas