Using Optical Coherence Tomography and Noninvasive Retinal Amyloid Imaging to Capture Retinal Changes Associated With Dementia
Oregon Health and Science University
Summary
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.
Eligibility
- Age range
- 55+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria for dementia subjects: * Physician-confirmed diagnosis of probable Alzheimer's disease * Mild dementia, as defined by score of 20 or greater on the Mini-Mental State Exam, or score of 15 or greater on the Montreal Cognitive Assessment, or Clinical Dementia Rating Scale score of 1. * Age older than 55 years. * Able to comply with study procedures * Corrected visual acuity at least 20/400 in either eye. * Has a legally authorized representative who can sign study consent form and accompany the participant to the OCT study visit. Inclusion Criteria for dementia-free controls:…
Interventions
- DeviceOptical Coherence Tomography Angiography (OCTA) Imaging
Optical coherence tomography is a non-invasive imaging technology that provides cross-sectional images of tissues in micron-scale resolution. The angiography component of this device allows for evaluation of blood vessel and blood flow changes in the eye. The Solix device with AngioVue software will be used to detect these blood vessel and flow changes as well as protein deposits in the retinal layers.
- DeviceNoninvasive Retinal Amyloid Imaging (NRAI)
The Spectralis will be used for NRAI. This system uses a special light source and optical filters to detect fluorescence of amyloid proteins in the eye.
Location
- Oregon Health & Science UniversityPortland, Oregon