Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Arkansas Children's Hospital Research Institute
Summary
This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes for children at high-risk for pulmonary invasive fungal infection (PIFI).
Eligibility
- Age range
- 0–21 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Males or females age \> 120 days and \< 22 years at any participating site * Have at least one of the following conditions associated with a known high incidence of IFI: hematopoietic stem cell transplantation (HSCT), aplastic anemia, bone marrow failure, primary or acquired immune deficiency, or malignancy * New (last 96 hours) radiographic evidence of at least one of the following: at least one nodular lesion greater than or equal to 5 mm in size, a wedge-shaped and segmental or lobar consolidation, a cavitary lesion, a lesion with a halo sign, a lesion with a reverse…
Interventions
- Diagnostic TestNon-Invasive Testing for PIFI
galactomannan assay, fungal PCRs, cell-free next-generation DNA/RNA sequencing, RNAseq
Locations (33)
- Arkansas Children's Research InstituteLittle Rock, Arkansas
- Rady Children's Hospital, UCSDLa Jolla, California
- Children's Hospital of Orange CountyOrange, California
- Lucile Packard Children's Hospital, Stanford UniversityPalo Alto, California
- University of California San Francisco, Benioff Children's HospitalSan Francisco, California
- Yale UniversityNew Haven, Connecticut