Hyperpolarized Pyruvate Imaging of Glioma: Imaging-Pathological Correlation
M.D. Anderson Cancer Center
Summary
This trial studies how an imaging agent, hyperpolarized carbon C 13 pyruvate, works in diagnosing glioma in patients with brain tumors. Giving hyperpolarized carbon C 13 pyruvate before an advanced imaging technique called a magnetic resonance spectroscopic imaging (MRSI) scan may help researchers better diagnose glioma in patients with brain tumors.
Description
PRIMARY OBJECTIVES: I. To establish a clinical infrastructure for performing hyperpolarized carbon C 13 pyruvate (hyperpolarized 13-C-pyruvate) imaging in the human brain at MD Anderson. SECONDARY OBJECTIVES: I. To assess the correlation between conversion rate of hyperpolarized pyruvate to lactate (kpl) values and Ki-67 quantitation in the tumor. II. To compare kpl values between tumor and normal brain within patient. III. To assess the association between kpl values and pathology results, including conventional, diffusion, perfusion, and permeability imaging. IV. To assess the associati…
Eligibility
- Age range
- 19+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Written informed consent will be obtained from each participants including healthy volunteers. * Healthy volunteers will not have contra-indications to MR scanning, but will otherwise not be subject to other selection criteria. * All patients will be enrolled in study # 2011-0370, the Stereotactic RadPath trial * Patient is \>18 years old, agrees to participate in the clinical study and to complete all required visits and evaluations. The pediatric population has a different disease profile from the glioma patients we hope to recruit. To reduce heterogeneity in the patie…
Interventions
- DrugHyperpolarized Carbon C 13 Pyruvate
Given IV
- ProcedureMagnetic Resonance Spectroscopic Imaging
Undergo MRSI
Location
- M D Anderson Cancer CenterHouston, Texas