Cognitive Training to Reduce Incidence of Cognitive Impairment in Older Adults
University of South Florida
Summary
Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residential care needs) and indirect (e.g., lost productivity of family caregivers) economic costs. Implementing interventions to prevent MCI and dementia among older adults is of critical importance to health and maintained quality-of-life for millions of Americans. Recent data analyses from the Advanced Cognitive Training in Vital Elderly study (ACTIVE) indicate that a specific cognitive intervention, speed of processing training (SPT), significantly delays the incidence of cognitive impairment across 10 years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across three years.
Description
Preventing Alzheimer's Disease with Cognitive Training: The PACT Trial The primary objective in the R56 phase was to establish the feasibility of the proposed field trial including meeting participant enrollment goals. The feasibility of the field trial was established by accruing 1000 enrolled participants. The secondary objective in the R56 phase was to ascertain participants' willingness to enroll in a longitudinal clinical trial and to subsequently complete a multispecialty clinical diagnostic evaluation, psychometric testing, MRI, PET scan, and genetic testing. Participants' willingness…
Eligibility
- Age range
- 65+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Be age 65 or older at time of consent * Have ability to speak and understand English or Spanish * Report adequate sensorimotor capacity to perform the computer exercises * Report adequate visual capacity to read from a computer screen at a typical viewing distance * Show adequate auditory capacity to understand conversational speech * Show adequate motor capacity to touch a computer screen or control a computer mouse. * Have no evidence of Mild Cognitive Impairment (MCI) or dementia, as assessed by the Montreal Cognitive Assessment score \>=26. * Have adequate mental hea…
Interventions
- BehavioralCognitive Training
Participants will be completing a total of 45 computerized sessions.
- BehavioralComputerized Cognitive Stimulation
Participants will be completing a total of 45 computerized cognitive stimulation sessions.
Locations (7)
- University of FloridaGainesville, Florida
- University of FloridaJacksonville, Florida
- University of North FloridaJacksonville, Florida
- The Roskamp InstituteSarasota, Florida
- University of South FloridaTampa, Florida
- Duke HealthDurham, North Carolina