Oxybutynin for Post-surgical Bladder Pain and Urgency
University of California, Davis
Summary
Bladder pain and urgency are common after bladder surgery. The objective is to determine if transdermal administration is superior to oral administration in alleviating pain and urgency.
Description
Pain after bladder surgery is typically controlled with narcotics, non-steroidal anti-inflammatory medications, acetaminophen, regional anesthesia (caudal or epidural) and/or bladder muscle (detrusor) antispasmodic medication. It is often difficult to distinguish bladder pain from a sensation of urinary urgency and most likely patients are experiencing both sensations despite the bladder being empty from the indwelling catheter. Prior studies on adults have demonstrated the efficacy of preoperative oxybutynin and other antimuscarinics on decreasing catheter-related bladder discomfort in the p…
Eligibility
- Age range
- 4–8 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients who will undergo bladder surgery that requires an indwelling bladder catheter after surgery. * Age Range: Four to 8 years of age are eligible for the study. Exclusion Criteria: * Patients who have had prior bladder surgery. * Patients who have neurologic disease that could impair bladder sensation. * Patients who are already taking antimuscarinic or antispasmodic medications. * Patients with glaucoma, any neurologic disease, dementia, impaired mentation or disorder of the central nervous system. * Patients taking any medication that affects the central nervous…
Interventions
- DrugOxybutynin Transdermal Patch
Transdermal patch of oxybutynin will be used instead of oral oxybutynin.
- DrugOral Oxybutynin
Oral administration of oxybutynin (5mg) every 8 hours in the hospital.
Location
- University of California Davis Medical Center (UCDMC)Sacramento, California