Animal and Plant Proteins and Glucose Metabolism

Summary

The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.

Eligibility

Age range

21–70 years

Sex

All

Healthy volunteers

Yes

Interventions

• Other
  High animal protein isolate

  Increased dietary protein content from animal protein isolates

• Other
  High animal protein whole food

  Increased dietary protein content from animal protein whole food

• Other
  High plant protein isolate

  Increased dietary protein content from plant protein isolates

• Other
  High plant protein whole food

  Increased dietary protein content from animal protein whole food

Location