Phenotyping Children and Adults With Possible High or Low Genetic Risk for Type 2 Diabetes
University of Pennsylvania
Summary
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
Description
The study team will recruit individuals based on genetic risk score for type 2 diabetes from the biobank populations who have agreed to be recontacted for future research. Each participant will undergo a frequently sampled four-hour oral glucose tolerance test and whole body DXA scan (dual-energy X-ray absorptiometry) in addition to baseline laboratory and history assessment.
Eligibility
- Age range
- 10–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age 10-70 years * Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research. * Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher Exclusion Criteria: * prior diagnosis of type 1, type 2, or secondary diabetes * use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication * acute illness that may impact insulin and glucose dynamics * pregnancy * hypothalamic obesity or related genetic disorder…
Interventions
- Other75g glucose beverage (Glucola, Trutol, or similar brand)
Subjects will present fasting to the study day and ingest the glucose beverage during the oral glucose tolerance test.
- OtherDXA, whole body
Subjects will undergo a whole body DXA scan for assessment of adiposity index and body fat distribution.
Locations (2)
- Childrens Hospital of PhiladelphiaPhiladelphia, Pennsylvania
- University of PennsylvaniaPhiladelphia, Pennsylvania