Forced Oscillometry in Infants With Bronchopulmonary Dysplasia
Winston Manimtim
Summary
The purpose of this study is to use forced oscillometry technique (FOT) to measure pulmonary mechanics and function in in term infants and premature infants with bronchopulmonary dysplasia (BPD)
Description
Pulmonary function testing has been the standard of care to diagnose and evaluate response to therapy in various respiratory diseases in adults and children. There are several equipment and techniques that are FDA approved for these purposes. However, there are currently no lung function tests that are practically feasible, clinically meaningful and widely used in infants. The forced oscillation technique (FOT) is a non-invasive method that had been used to measure respiratory mechanics. FOT employs small amplitude pressure oscillations superimposed on the normal breathing and therefore has t…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Preterm Cohort: * Premature infants with BPD who are in room air based on the (per NICHD definition) * Premature infants with BPD who are receiving low flow O2 support and able to maintain normal spO2 in Room air for brief period ( up to 3 minutes) Term Cohort without pulmonary disease * Infants \>36 weeks gestational age without pulmonary disease * Infants \< 4 weeks of age Outpatient Cohort: * Former preterm infants \< 32 weeks at birth * Those with BPD based on NIH 2001 definition * Seen prior to 2 years of age Exclusion Criteria: * Infants with BPD requiring invas…
Interventions
- DeviceNon-invasive forced airway oscillometry
This non-invasive device will measure pulmonary mechanics in spontaneously breathing premature infants and term infants without pulmonary disease. Infant will be in supine position and breathing regularly. A cushioned mask will be placed on the infant's face, covering the nose and mouth. Measurements typically take less than 20 seconds and no more than 3 repetitions will be done at each time point.
Location
- Children's Mercy HospitalKansas City, Missouri