Mechanisms and Modulation of Pain Modulatory Capacity
University of Florida
Summary
This project proposes to understand the sources of pain variability, and demonstrate that pain variability represents fluctuation in natural pain management. The project further proposes to determine if endogenous capacity to modulate pain can be trained to maximize their body's ability to manage pain, much as the way in which athletic performance can be trained.
Description
Many physiological systems (bioenergy, immune etc.) involve feedback mechanisms to respond to challenges, with increased output or capacity for adaptive change. A similar process is plausible for pain modulation where previous successful pain experience and resolution suggests a pain modulatory system with adaptive capacity. The proposed research examines how a musculoskeletal training program modulates pain response in people with fibromyalgia compared to healthy individuals. Previous research suggests that moderate-high level exercise is associated with attenuation of pain sensitivity and cl…
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Asymptomatic people (ie no current pain conditions) * Participants with widespread muscle pain (WMP) aged 18 years of age and older * Participants with WMP must meet the ACR (2010) diagnostic criteria of multiple regions of muscle pain * The asymptomatic group will be free of current wrist/hand, elbow, or shoulder pain and chronic pain conditions (eg irritable bowel syndrome, FM) Exclusion Criteria: 1. Participation in a conditioning program specific to the biceps in the past 6 months 2. Any report of wrist/hand, elbow, or shoulder pain in the last 3 months 3. Any chro…
Interventions
- BehavioralDelayed onset muscle soreness.
Participants will perform a fatiguing exercise protocol for the upper extremity (biceps muscles)
Location
- Unversity of FloridaGainesville, Florida