Testing the Efficacy of Multi-day Interruptions in Sedentary Behaviors on Metabolic, Cognitive, and Affective Outcomes in Youth at Risk for Type 2 Diabetes
University of Southern California
Summary
The overall objective of this in-lab randomized controlled trial is to test the efficacy of multi-day interruptions in sedentary behavior vs. single bouts of sustained exercise on metabolic, cognitive, affective, and cardiac autonomic nervous system responses in children with overweight and obesity who are at risk for type 2 diabetes. The use of continuous glucose monitoring will provide insight into the daily and cumulative metabolic effects of each condition that have thus far not been studied. In-lab studies demonstrating sustained efficacy of this approach in ameliorating negative effects of sedentary behaviors in children are necessary for the optimization of field-based interventions. Given the lack of success of interventions to prevent obesity-related diseases and increasing rates of type 2 diabetes in children and its related healthcare costs, this study addresses a critical public health need by testing of novel intervention strategies to reduce obesity-related diseases in children with overweight and obesity.
Description
Rationale: Sedentary behavior (SB) contributes to increased risk for obesity and metabolic disease, cognitive deficits, affect disorders, and cardiovascular disease over the lifespan. These are critical outcomes because children with these risk factors are more likely to develop type 2 diabetes mellitus (T2DM). SB increases T2DM risk by promoting hyperglycemia and greater postprandial glycemic variability as well as via cognitive detriments and depressive symptoms that lead to poor energy balance behaviors, obesity, and worsening insulin resistance. Additionally, prolonged SB may contribute to…
Eligibility
- Age range
- 8–11 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Age 8-11 years-old 2. Good general health 3. BMI≥85th percentile Exclusion Criteria: 1. Significant cardiac or pulmonary disease likely to or resulting in hypoxia or decreased perfusion 2. Diagnosis of T2DM and/or presence of other endocrinologic disorders leading to obesity (e.g., Cushing Syndrome) 3. Current or past anti-psychotic drug use that would affect metabolism 4. Non-diet treatment for hypertension or dyslipidemia 5. Precocious puberty and/or receiving androgen and estrogen therapy 6. Medication use known to affect body composition/weight
Interventions
- BehavioralSIT+WALK
Participants will interrupt their sitting for one week
- BehavioralEX
Participants will perform a single bout of exercise and then sit for the remaining time for one week
Location
- Britni Ryan Belcher, PhD, MPHLos Angeles, California