Tfh Dysfunction in HIV and Aging
University of Miami
Summary
The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people to understand how aging and HIV infection affect the immune responses (body defenses against infection) to the flu vaccine.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. For HIV positive participants: * HIV infection, as documented by any licensed ELISA test kit. Participants on ART as a result of prior HIV documented infection will not be required to provide proof of diagnosis of HIV infection. * Additional criteria for HIV positive 1. on ART for at least 1 year. Occasional viral blips up to 1000 copies/ml also acceptable provided the patients are on continuing treatment, 2. Cluster of differentiation 4 (CD4) count available in the prior 6 months and \>200/mm3 3. Undetectable viral load (\< 40 copies/mL). Blips o…
Interventions
- BiologicalStandard dose influenza vaccination
Single 0.5 ml injection administered intramuscularly into participant's deltoid muscle
- BiologicalHigh dose influenza vaccination
4 times more concentrated single 0.7 ml injection administered intramuscularly into participant's deltoid muscle
Location
- University of MiamiMiami, Florida