Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment
University of California, Los Angeles
Summary
The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll MCI subjects and subjects with subjective memory complaints who will be randomly assigned to receive active or sham brain stimulation. 'Blinded' or 'sham-controlled' means that the subject will not know whether the treatment they receive is the active treatment or the non-active stimulation. In the 'sham' condition, the stimulator will turn on but will not actually be stimulating the target brain region.
Eligibility
- Age range
- 55–100 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Agreement to participate in the study * 55-100 years of age * Right-handedness * In good general health * Living independently * Subjective memory complaints (self-report and positive score on MFQ) * Katz ADL scale and Lawton iADL scale: We will review scores on a case-by-case basis if they did not score 100%. We will exclude if the scores show impairment in ADLs that suggests problems with independent functioning due to cognitive impairment. * MMSE score \> 24 * PHQ Depression score =\< 7 * Ability to read, write, and speak English fluently * Diagnosis of mild neurocogn…
Interventions
- DeviceActive Theta Burst Stimulation
Theta burst transcranial magnetic stimulation (TBS) will be delivered at 80-100% of motor threshold (MT).
- DeviceSham Theta Burst Stimulation
Sham stimulation will be delivered at 0-10% of motor threshold (MT), with all other parameters matching the active TBS condition.
Location
- University of California Los AngelesLos Angeles, California