The Role of Diet and the Microbiome in Inducing Somatic Mutations in Colorectal Epithelial Cells and Its Predisposition to Carcinogenesis - A Pilot Study
M.D. Anderson Cancer Center
Summary
This study is to learn more about how diet affects the microbiome (bacteria and microorganisms) of the digestive system. Researchers want to learn if this, in turn, has an effect on if and how people then develop colorectal cancer.
Description
PRIMARY OBJECTIVES: I. To evaluate the differences in dietary patterns among individuals reporting to be vegetarian and omnivorous. II. To compare the difference in stool microbiome pattern in the above mentioned two groups of individuals. III. To compare somatic mutations in colorectal epithelial cells in the above mentioned two groups of individuals. SECONDARY OBJECTIVE: I. To identify and characterize an association between diet, the microbiome and its genotoxic effect on the colorectal epithelial cells and predisposition to colorectal carcinogenesis. OUTLINE: Participants complete d…
Eligibility
- Age range
- 45+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * GROUP I: Patients presenting for a screening colonoscopy * GROUP I: Age of 45 and above * GROUP I: Strict vegetarian diet, determined by using diet history questionnaire 3.0 National Institutes of Health (NIH) * GROUP I: Non smoker * GROUP I: Ability to understand and willingness to sign an informed consent form, complete web based dietary assessment and provide stool, colonic mucosa and blood samples * GROUP II: Patients presenting for a screening colonoscopy * GROUP II: Age of 45 and above * GROUP II: Omnivorous diet * GROUP II: Non smoker * GROUP II…
Location
- M D Anderson Cancer CenterHouston, Texas