Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study
Memorial Sloan Kettering Cancer Center
Summary
The purpose of this study is to see if Cs-131 brachytherapy is effective in people with recurrent brain cancer who are scheduled to have brain surgery for removal of their tumor(s). The researchers would like to see whether Cs-131 prevents brain tumors from growing back after surgery.The researchers will compare Cs-131 brachytherapy (which occurs during brain surgery) with the usual approach of brain surgery without brachytherapy. The researchers will compare both the effectiveness and safety of the two approaches.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adult patients ≥ 18 years of age who are capable of giving consent * Undergoing elective craniotomy for resection of a previously-irradiated brain metastasis with suspicion for viable disease at the time of consent, and anticipated achievement of gross-total or near-total (\>/=95%) resection * Karnofsky Performance Status score (KPS) of ≥70 * Ability to undergo brain MRI with gadolinium Exclusion Criteria: * Unable to tolerate MRI or CT imaging * Pregnancy (patients must have a negative pregnancy test within 30 days of the operation) * Women must agree to not breastfee…
Interventions
- ProcedureCraniotomy
Craniotomy
- RadiationCesium-131 brachytherapy
Intracavitary Cesium-131 brachytherapy
Locations (6)
- Baptist Health South FloridaMiami, Florida
- Memorial Sloan Kettering at Basking Ridge (Consent Only)Basking Ridge, New Jersey
- Memorial Sloan Kettering Monmouth (Consent Only)Middletown, New Jersey
- Memorial Sloan Kettering Commack (Consent Only)Commack, New York
- Memorial Sloan Kettering Cancer CenterNew York, New York
- Memorial Sloan Kettering Nassau (Limited Protocol Activities)Uniondale, New York