Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
University of California, Davis
Summary
The primary objective of this study is to determine if the peri and post operative use of gabapentin in children reduces the need for narcotics after thoracic surgery. We hypothesize that patients who are given gabapentin will need fewer morphine equivalents postoperatively than those who were not given gabapentin
Description
This study is a double-blind, placebo controlled, randomized study to explore the effects of gabapentin peri and post operatively. Physician and families will be blinded to the treatment. 60 subjects will be randomized in a 1:1 ratio to either: * Gabapentin treatment group * Placebo - control group We aim to understand the impact that gabapentin use peri and post operatively has on: 1. opioid use based of IV morphine 2. pain scores 3. opioid related complications such as withdrawal 4. effects on the level of sedation 5. Possible adverse effects associated with use of gabapentin 6. Time to…
Eligibility
- Age range
- Up to 17 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age newborn to \< 18 years. 2. Gestational age to be minimum 38 weeks. 3. Undergo cardiac surgery via a sternotomy or thoracotomy. OR Any Thoracic Surgery OR Planned noncardiac surgery via a thoracotomy or Video Assisted Thoracotomy (VATS). 4. Surgery will result in an inpatient stay of at least 48 hours. Exclusion Criteria: 1. Use of opioids within 30 days prior to study entry. 2. Renal Failure as defined by RIFLE Criteria. 3. History of seizures requiring active treatment. 4. History of chronic pain treated medically. 5. Diagnosis of Autism. 6. Unable to tolerate en…
Interventions
- DrugGabapentin
Determine if the peri and post operative use of gabapentin in children reduces the need for narcotics after surgery.
- OtherPlacebo
Control Arm
Location
- UC Davis Medical CenterSacramento, California