Investigating Inhibitory Control Networks in Parkinson's Disease
University of Alabama at Birmingham
Summary
The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor. These movement disorders commonly have significant non-motor features also, including depression, cognitive impairment, decreased attention, and slower processing speeds. The investigators are interested in the brain activity associated with these symptoms, and perform recordings of the surface of the brain, in addition to the typical recordings the investigators perform, during routine deep brain stimulation (DBS) surgery.
Description
Movement disorders are a prominent cause of disability worldwide. In the United States, it is estimated that more than 4 million people suffer from Parkinson's disease (PD), essential tremor (ET), and dystonia, some of the most prevalent of neurologic disorders. Of these, PD is the most common, and is primarily characterized by tremor, rigidity, and bradykinesia. However, many patients also have prominent non-motor features, including depression and cognitive impairment, with deficiencies in processing speed, memory, attention, and learning. One of the most debilitating cognitive deficiencies…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Eligible for surgery based on multi-disciplinary consensus review * Have a diagnosis of Parkinson's disease or Essential Tremor * Have a diagnosis of medically-refractory movement disorder (Parkinson's disease, Essential Tremor, or dystonia) * Willingness to participate in the paradigms described in the protocol Exclusion Criteria: * Inability to provide full and informed consent * Age younger than 18 * Are not able to participate in study-related activities * History of prior ischemic/hemorrhagic stroke, subdural hemorrhage, or seizure
Interventions
- OtherProcedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease
After creation of the burr hole and prior to DBS electrode placement, 1-2 subdural strip electrodes will be placed anteriorly or posteriorly from the cranial opening. These electrodes are routinely placed using this technique for seizure mapping, with arrays of electrodes (up to 6) being placed around the perimeter of the opening.14 Subdural strips vary in length and contact size (e.g., the 6-contact Ad-Tech strip), and are currently placed predominantly for studies of sensorimotor function,13 including at our institution (IRB-140327003). Placement over prefrontal areas is performed at other institutions.11-13 The DBS surgery will then proceed according to routine practice, and following lead placement in the optimal desired location, the research task paradigm will begin.
Location
- University of Alabama at BirminghamBirmingham, Alabama