Uncovering the Impact of Diet on the Human Circadian Timing System
Oregon Health and Science University
Summary
The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to elucidate the speed of entrainment in response to a high-fat diet.
Description
Synchronization of the timing of biological processes and behaviors with the 24-hour light-dark cycle is fundamental to almost every physiological process, cognitive function, and overall health. As the average circadian period in humans is \~9 min longer than the 24-h day, and artificial lighting allows a further delay in the clock, circadian entrainment must occur every day. This makes the process of circadian entrainment of the internal clock with the external environment a commonly overlooked process, but one that has serious ramifications if impaired. In rodent models, high-fat diets hav…
Eligibility
- Age range
- 18–40 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Healthy, lean men and women Exclusion Criteria: * Major dietary restrictions (such as entirely dairy-free and/or meat-free diets) * A body mass index (BMI) of 18.5\< \[BMI\] \< 24.9 kg/m\^2 and a waist circumference \<94/80cm * Currently psychiatrically/psychologically unsuitable for participation * Drug/alcohol use, including smoking * Medication/drug use, including prescribed and over-the-counter medications * History of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study. * Traveled across more than 1 t…
Interventions
- OtherHigh-Fat Diet
The diet will consist of a breakfast, lunch, dinner, and snack
- OtherLow-Fat Diet
The diet will consist of a breakfast, lunch, dinner, and snack
Location
- Oregon Health & Science UniversityPortland, Oregon