Wake Forest University Health Sciences
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.
Inclusion Criteria: * verified HIV status * Current marijuana use (MJ+ groups only) * No current marijuana use (MJ- groups only) * current engagement in HIV care (HIV+ participants only) * receipt of cART as first-line of treatment (HIV+ participants only) * stable cART regimen (HIV+ participants only) * undetectable HIV RNA viral load for \>1 year (HIV+ participants only) Exclusion Criteria: * Lifetime abuse for any illicit drug other than marijuana * \<9th grade education; illiteracy or lack of fluency in English * history of moderate or severe head trauma * unstable or serious neurologic…
The investigators will use multimodal, multi-parametric sequences to investigate neuroinflammatory and neurodegenerative processes in vivo. Participants will be assessed three times over 2 years.
Blood samples will be collected for immune and cytokine profiling. Participants will be assessed three times over 2 years.
Participants will have neuropsychological testing three times over 2 years.
Arctuva estimate
Verify or correct the compensation shown for this listing.