Brigham and Women's Hospital
The goal of this clinical trial is to test whether our dietary intervention can prevent or lessen the negative health effects of night shift work in healthy participants. Participants will: * complete 2 inpatient stays * be provided with identical meals * have frequent blood draws * provide urine, saliva, stool and rectal swab samples
Shift work increases the risk for diabetes possibly due to the adverse metabolic effects of circadian misalignment. As shift work is not foreseen to disappear, the development of individually-targeted therapies for metabolic health in these vulnerable shift workers is urgently needed. This research will determine whether our dietary intervention can mitigate the adverse metabolic effects of circadian misalignment, which may help in the design of evidence-based dietary interventions to improve the metabolic health in shift workers.
Inclusion Criteria: * 18-45 yr old * BMI 20.0-29.9 * European/Hispanic/African-American ancestry * No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.) Exclusion Criteria: * Currently smoking/vaping or 5 or more years of smoking/vaping * History of drug or alcohol dependency * History of psychiatric illness or disorder
Research participants will be assigned to two dietary conditions.
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