Do Endotypes Predict Response and Sequelae in OSA Patients
University of California, San Diego
Summary
This study will investigate why some people have Obstructive Sleep Apnea (OSA) and how the underlying cause may relate to OSA manifestations (including sleepiness and high blood pressure) and response to different therapeutic approaches (ie CPAP, eszopiclone, and supplemental oxygen). Understanding why someone has OSA could affect how best to treat that individual, but may also have an impact on what problems the disease might cause.
Eligibility
- Age range
- 21–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Ages 21-65 years old * Men and women with a physician diagnosis of OSA (or strongly suspected to have sleep apnea - \* see below) * BMI 20 - 35 kg/m2 Exclusion Criteria: * Pregnancy (current or planned) * Nursing * Inability to provide self-consent or complete study procedures, such as questionnaires that are only available/validated in English. * Already on effective therapy and adherent to treatment for OSA * Other known untreated sleep fragmenting disorder, such as periodic limb movement disorder, or narcolepsy * Circadian rhythm disorder * Unrevascularized coronary…
Interventions
- DrugEszopiclone
2mg of Eszopiclone just before going to sleep.
- OtherSupplemental Oxygen
Constant oxygen flow at 4 Liters per minutes for the duration of time in bed via nasal cannula.
- DeviceContinuous Positive Airway Pressure (CPAP)
A standard CPAP device will be provided using the settings as prescribed by the treating physician.
Location
- Altman Clinical and Translational Research Institute BuildingLa Jolla, California