RTMS Manipulates Imbalanced Drive-reward and Executive Control Circuitry for Smoking Cessation
Medical University of South Carolina
Summary
Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel, non-pharmacological interventions for depression and cigarette smokers. In this study, investigators will use brain MRI to guide TMS therapy for smoking cessation.
Description
Smoking cessation is difficult, despite the demonstrated efficacy of several pharmacotherapeutic agents and cognitive behavioral therapies. This may be due to imbalanced neuronal circuits, including elevated functional connectivity in the drive-reward circuit (medial orbital frontal cortex \[mOFC\] to nucleus accumbens \[NAc\]) and decreased functional connectivity in the executive control circuit (dorsolateral prefrontal cortex\[ DLPFC\] to NAc). Repetitive transcranial magnetic stimulation (rTMS) is a new class of therapeutics that has already displayed remarkable potential for producing nov…
Eligibility
- Age range
- 22–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria * Be between the ages of 22 and 70 years old. * Smoke 10 or more cigarettes per day and have a carbon monoxide (CO) level \> 10 ppm indicative of recent smoking. * Have not received substance abuse treatment within the previous 30 days. * Meet the criteria for tobacco use disorder as determined by DSM-5. * Be in stable mental and physical health. * If female, test non-pregnant and use adequate birth control. * Show no evidence of focal or diffuse brain lesions on MRI. * Be willing to provide informed consent. * Be able to comply with protocol requirements and likely to c…
Interventions
- DeviceSham rTMS
Two electrodes on the scalp will be connected to transcutaneous electrical nerve stimulation.
- DeviceActive rTMS 10 Hz DLPFC
10 Hz repetitive transcranial magnetic stimulation (rTMS) will be delivered over left dorsolateral prefrontal cortex (DLPFC).
Locations (2)
- Medical University of South CarolinaCharleston, South Carolina
- Medical University of South CarolinaCharleston, South Carolina