Understanding Motivation in Parkinson's Patients Through Neurophysiology
University of California, San Francisco
Summary
The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation to effort, reward, and timing.
Description
Participants will perform reward-based decision-making tasks designed to assess both self-benefitting and prosocial motivation. The tasks will evaluate how effort and reward influence decision-making, as well as how proximity to a deadline impacts choices. These tasks will be conducted in both clinic and home settings. Throughout the study, participants will remain on their regular dopaminergic medications. Each participant will complete sessions under two stimulation conditions: their usual DBS settings and with DBS turned off. Neural activity will be recorded using the Percept device, which…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Has Parkinson's Disease or Dystonia * Has Medtronic Percept or RC+S DBS device implanted in either GPI or STN * Has DBS device implanted either bilaterally or unilaterally * Male or female * More than 1 month post-DBS surgery Exclusion Criteria: * Severe cognitive impairments * Has MOCA score below 20 * Pregnancy * Age less than 18 years old
Interventions
- OtherStimulation on
Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.
- OtherStimulation off
Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.
- BehavioralDecision Making Task
Patients will be playing a decision making task through a computer-based application.
Location
- University of California San FranciscoSan Francisco, California