Feasibility Study on Radiofrequency-Based Selective Electrothermolysis to Investigate Its Effects on Human Skin
Johns Hopkins University
Summary
This research is being done to assess the effect of radiofrequency (RF)-based treatment on skin and skin conditions.
Description
Radiofrequency (RF)-based selective electrothermolysis is an increasingly utilized minimally invasive technology for several dermatologic conditions, such as epilation, acne vulgaris, and skin rejuvenation, with minimal side effects. This procedure targets and destroys selective cutaneous and subcutaneous structures; therefore, allowing greater control and specificity of treatment area and minimizing destruction to surrounding tissue. Here, the investigators propose to utilize this technology on human axillary skin to establish safety and biologic effects of selective electrothermolysis in thi…
Eligibility
- Age range
- 22–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. For primary objective: healthy volunteers and HS patients between 22 and 70 years of age. 2. Participants must be healthy enough to undergo multiple skin biopsy in the opinion of the investigator. 3. Participants must provide informed consent. 4. Participants must have the ability and willingness to follow all study procedures, attend scheduled visits, and successfully complete the study. 5. Participants must have the ability to understand and communicate with the investigator. 6. For HS patients, participants will have localized disease to the axillae, mild to moderate…
Interventions
- DeviceRadiofrequency-Based treatment
RF-based treatments use electrothermolysis to deliver heat energy to targeted structures in the skin, such as hair follicles or glands by the use of insulated needles. The investigators will use radio frequency based treatment on a pre-selected skin area (about 3cm x 3cm or 1 ¼ x 1 ¼ inches in size) on either your left or right underarm that is eligible for assessment, study treatment, and biopsy. Participants will receive clinical assessments, photography, questionnaires, up to 3 treatments of RF-based selective electrothermolysis to pre-selected areas of the axillary skin, up to 2 4-mm skin biopsies for up to 5 study visits.
Location
- Johns Hopkins School of MedicineBaltimore, Maryland