Liquid Biopsies in Non-CNS Malignant Pediatric Solid Tumors
Children's Hospital Los Angeles
Summary
This study is being done to determine if traces of tumor can be found in the blood before, during, and after patients stop treatment. We will analyze the tumor material to see if it is similar to tumor tissue and if the tumor material in blood is helpful in monitoring the disease.
Description
Liquid biopsies, particularly those involving cell-free DNA (cfDNA), are a promising non-invasive, cost effective method of monitoring disease in cancer patients with solid tumors and are being increasingly employed in various adult malignancies to diagnose disease, monitor tumor response, detect relapse and learn more about tumor biology. The utility of liquid biopsies which may include isolation and analysis of tumor derived material such as DNA, RNA, intact cells, proteins, or exosomes from blood or other bodily fluids in pediatric solid tumors has not been established. In this study, we pr…
Eligibility
- Age range
- 0+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Newly diagnosed, relapsed, or refractory histologically confirmed high grade bone or soft tissue sarcoma or malignant renal, thyroid, germ cell, or hepatic tumors, OR * Healthy individual with no history of cancer or chronic medical problems and \< 21 years of age Exclusion Criteria: * CNS Malignancies * Individuals \< 6 months of age
Interventions
- OtherBlood Draw
Blood draw at baseline, disease evaluation time point, and pre and post surgery and/or radiation.
Location
- Children's Hospital Los AngelesLos Angeles, California