A Phase 1, First in Human, Dose-Escalation Study of TORL-1-23 in Participants With Advanced Cancer
TORL Biotherapeutics, LLC
Summary
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-1-23 in patients with advanced cancer
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Advanced solid tumor * Measurable disease, per RECIST v1.1 * Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * Adequate organ function Exclusion Criteria: * Has not recovered \[recovery is defined as NCI CTCAE, version 5.0, grade ≤1\] from the acute toxicities of previous therapy, except treatment-related alopecia or laboratory abnormalities otherwise meeting eligibility requirements * Received prior chemotherapeutic, investigational, or other therapies for the treatment of cancer within 14 days with small molecule and within 28 days with biologic befo…
Interventions
- DrugTORL-1-23
antibody drug conjugate (ADC)
Locations (14)
- Providence Medical FoundationFullerton, California
- UCLA - JCCC Clinical Research UnitLos Angeles, California
- University of Kentucky Medical CenterLexington, Kentucky
- University of MinnesotaMinneapolis, Minnesota
- Mayo Clinic in RochesterRochester, Minnesota
- Memorial Sloan Kettering Cancer CenterNew York, New York