Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction
UConn Health
Summary
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
Description
This is a prospective pilot study to evaluate changes before and 4 weeks(+/- 1 week) after beta-blocker withdrawal in 30 HFpEF patients. The study involves 2 visits that are 4 weeks apart. The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram. No long term follow up beyond the 2nd visit.
Eligibility
- Age range
- 50–80 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100 * N=30 (Target: 30). * Age: 50 \~ 80 years. * ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction. * Chronic loop diuretic use * Currently on beta-blocker Exclusion Criteria: * Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease. * Heart rate \> 100 bpm * Recent hospitalization due to HF within 3 months * Non-English speaker
Interventions
- Otherbeta blocker discontinuation
beta blocker discontinuation
Location
- UConn Health / John Dempsey HospitalFarmington, Connecticut