Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Summary
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.
Description
Background: Seventy percent of adults with cerebral palsy (CP) have chronic pain. Patterns in pain symptoms suggest that different individuals have different types of pain. People with CP have differences in brain structure and function, but links with pain mechanisms are not well-understood. Better understanding could help inform precision diagnosis and management of pain subtypes in individuals with CP. Objectives: Primary: Identify and characterize sensorimotor network disruption patterns associated with chronic pain and motor deficits in CP Secondary: * Improve understanding of anatomi…
Eligibility
- Age range
- 8+ years
- Sex
- All
- Healthy volunteers
- Yes
Participants with CP (Survey-only): Inclusion Criteria: * Individual 8+ years of age * Diagnosis of cerebral palsy Exclusion Criteria: -None Neurotypical participants: (Survey-only): Inclusion Criteria: * Individual 8+ years of age * Adult subject able to indicate understanding and affirmative consent OR Adult/child subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents Exclusion Criteria: -Clinically-significant neurologic or developmental diagnosis Participants with CP (Survey and MRI): Inclusion Criteria: * Individual 8+ years of ag…
Interventions
- Diagnostic TestMRI
Research unsedated MRI scans (outside of usual care) will be performed using a 3T Philips scanner at the F.M. Kirby Research Center. An MRI scanning protocol will be at the F.M. Kirby Research Center; the protocol will not last more than 1.5 hours. Acquisitions will include a triplanar survey, functional and anatomical multi-slice imaging of the brain as well as MRI of selected spinal levels. Protocols will be used that do not involve use of contrast agents and limit power/tissue absorption as well as otherwise remain within FDA and Kirby Center safety regulations. When possible, MRI will be performed within 3 months of initial survey/interview administration. If MRI is scheduled \>3 months after initial survey/interview administration, a brief survey will be re-administered to screen for changes in pain/clinical status.
Locations (4)
- F.M. Kirby CenterBaltimore, Maryland
- Mt. Washington Pediatric HospitalBaltimore, Maryland
- Johns Hopkins HospitalBaltimore, Maryland
- Kennedy Krieger InstituteBaltimore, Maryland