Lifestyle Patterns and Glycemic Control
Columbia University
Summary
The goal of the proposed study is to evaluate the feasibility and initial efficacy of stabilizing lifestyle behaviors to improve glucose control and body composition in patients with pre-diabetes. The investigator proposes that following stable lifestyle behaviors will improve patients' glucose control, body composition, and liver fat. The results from this study has the potential to impact clinical practice and patient care.
Description
Variability in lifestyle behaviors has been associated with adverse health, specifically poor glucose control. The project proposes to test whether reducing this variability improves glycemia in patients with pre-diabetes. If successful, this simple positive lifestyle message to keep stable behaviors has the potential to improve the health of millions of adults worldwide. This project will enroll participants with pre-diabetes who have erratic lifestyle behaviors and randomize them to either maintain their usual habits (control group) or stabilize their behaviors (stability group). Both group…
Eligibility
- Age range
- 25+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Pre-diabetic kg/m2 (hemoglobin A1c 5.7-6.9%) * 25 years or older * BMI between 25-39.9 kg/m2 * Sleep duration ≥6 hours a night assessed with wrist actigraphy (for 14 nights) * Variable bedtime, SD≥45 minutes. Exclusion Criteria: * Chronic Kidney Disease (GFR\<60) * Uncontrolled hypertension (≥160/100 mmHg) * Obstructive Sleep Apnea * Psychiatric or neurological disorder * Prevalent cardiovascular disease * Dyslipidemia (triglycerides≥200 mg/dL) * Medications that affect insulin sensitivity, glucose concentrations, and body weight * Non-day or rotating shift workers * T…
Interventions
- BehavioralFixed Schedule
Participants will be asked to maintain a fixed schedule for 12 weeks.
Location
- Columbia University Irving Medical CenterNew York, New York