Understanding the Burn Wound Microbiome: Comparing Traditional Wound Cultures to Next Generation Sequencing Technology
The University of Texas Medical Branch, Galveston
Summary
The purpose of this investigation is to better understand the wound microbiome in burn wounds and the role it plays in outcomes and complications related to treatment.
Description
1. \- INTRODUCTION: The human microbiome consists of microorganisms including bacteria, fungi, archaea and viruses that live in association with the body. In the average person, bacteria alone outnumber host cells ten-fold and contain a thousand more genes than the human genome. Therefore, despite consisting of \<3% of the body's biomass, the human microbiome plays a crucial role in establishing and maintaining the complex biomechanics of our health and development. In the last two decades, the NIH Human Microbiome Project has spotlighted a number of newly discovered influences the microbiome…
Eligibility
- Age range
- 18–100 years
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: * All adult patients (18 years of age and greater) admitted to or consulted by the Acute Burn Surgery service with a diagnosis of a partial thickness or full thickness burn wound determined by the Acute Burn Surgery service to be appropriate for operative intervention. We will include patients 18 years of age and older of any gender, race, prior therapy, or pre-existing medical condition. We will also include subjects in special classes, including pregnant women and cognitively impaired persons. Exclusion Criteria: * Children (less than 18 years of age) will be excluded.…
Location
- University of Texas Medical BranchGalveston, Texas