Qualification for Cone-Optogenetics (EyeConic)
Institute of Molecular and Clinical Ophthalmology Basel
Summary
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Description
In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them through targeted optogenetic tools. However, the true proportion of low vision patients harboring dormant, non-functional cones, is currently unknown. The worldwide multicenter retrospective study (EyeConic) aims to estimate the proportion of low vision patients with remaining cone cell bodies for the first time.
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria (patients): * Diagnosis of generalized IRD * Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye * Availability of macular optical coherence tomography (OCT) Inclusion Criteria (controls): * Normal ophthalmic findings * Availability of macular optical coherence tomography (OCT) Exclusion Criteria (all): * Other eye diseases with a significant effect on vision or retinal structure * Extraocular disease affecting retinal structure such as neurodegenerative diseases
Interventions
- Diagnostic TestOptical coherence tomography (OCT)
Data of macular optical coherence tomography (OCT)
Locations (9)
- University of California San Francisco, Department of OphthalmologySan Francisco, California
- Bascom Palmer Eye InstituteMiami, Florida
- University of Pittsburgh, Department of OphthalmologyPittsburgh, Pennsylvania
- Beijing Institute of OphthalmologyBeijing
- Universitätsklinikum Tübingen AugenklinikTübingen
- Semmelweis University, Department of OphthalmologyBudapest