Boston VA Research Institute, Inc.
Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.
Here, the investigators propose that neurofeedback aimed to regulate the superior temporal gyrus (STG) activation will not only lead to activation changes in the STG, but also to changes in the default mode network (DMN), as well as to reductions in AH, and that the brain and clinical changes will be correlated. The theoretical framework for the current proposal is an AH model that assumes that AH result from abnormalities in a network of regions including STG, and medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC), the two latter regions are core medial hubs of DMN that are…
Inclusion Criteria: * patients diagnosed with SZ or schizoaffective disorder using DSM-5 criteria * auditory hallucinations not responsive to pharmacology as determined by chart review and a clinical interview of SCID. Exclusion Criteria: * neurologic illness * major head trauma * electroconvulsive therapy * alcohol or drug dependence * alcohol or drug abuse within the past five years * verbal IQ below 70
the patients will receive real-time feedback from the brain activity of the superior temporal gyrus
the patients will receive real-time feedback from the brain activity of the somato-motor cortex
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