Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial
Nebraska Methodist Health System
Summary
Randomized trial comparing risk of hospital readmission and hypertensive complications between patients managed on Labetalol compared to Nifedipine.
Description
Enrollment: Patients will be identified daily using an EMR screening tool. Those that meet inclusion criteria will then be approached by the investigators or research RN for enrollment. Patients consenting to be involved in the study will then be randomly assigned to the nifedipine or labetalol arms of the study. Block randomization will be performed in blocks of 50 with goal of 600 total patients (300 in each arm). Treatment Protocols Nifedipine Study Arm: Patients randomized to Nifedipine will be started on Nifedipine XR 30mg BID. Escalation in therapy to be determined by primary provide…
Eligibility
- Age range
- 19+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: Any patient admitted for delivery by cesarean or vaginal delivery at 24 weeks gestation or greater with hypertension(HTN). Hypertension will be defined during the study as either a systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg on two occasions at least 4 hours apart. This definition is consistent with the ACOG definition for pregnancy related HTN. Following enrollment, treatment will be escalated at discretion of primary provider with the goal of normotension. Exclusion Criteria: History of moderate persistent asthma, coronary artery disease, heart…
Interventions
- DrugLabetalol Oral Tablet
See Labetalol arm.
- DrugNIFEdipine ER
See Nifedipine arm.
Location
- Nebraska Methodist Women's HospitalOmaha, Nebraska