Oxalate and Citrate in Humans
University of Chicago
Summary
This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.
Description
Experimental Design and Implications Administration of oral oxalate without citrate will determine the contribution of diet to this association. We will measure fractional excretion of oxalate and citrate. Both are freely filtered by the glomerulus and either secreted or reabsorbed (oxalate) or just reabsorbed (citrate). We will be able to assess urine excretions partitioned from the contribution of the filtered load and subsequent tubule handling by using fractional excretion. This study has large implications for both patient care and future studies. If the urine oxalate-citrate association…
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Stone formers: * Age 18-70 * History of at least one calcium-based kidney stone Non-stone formers (controls): * Age 18-70 * No history of kidney stone * 24-hour urine oxalate within lab normal (\<50mg/day) Exclusion Criteria: * History of primarily uric acid, cysteine, or struvite stones. * History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate. * Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period. * Non-stone f…
Interventions
- OtherKidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic
Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic Subjects in both arms will be asked to partake in the same activities, as follows: The day before presenting to the research clinic subjects will collect urine at home. Subjects will will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. We will give them a special liquid that contains oxalate, and they will receive a specially prepared breakfast that is low in oxalate and citrate. After this, we will collect urine and blood throughout the day. While at the clinic, subjects will also receive specially prepared snacks.
Location
- University of Chicago Medical CenterChicago, Illinois