An Exploratory Phase 1b/2a Multicenter, Open-Label, Novel-Novel Combination Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of CC-92480 (BMS-986348) in Novel Therapeutic Combinations in Participants With Relapsed or Refractory Multiple Myeloma
Bristol-Myers Squibb
Summary
The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Relapsed or refractory multiple myeloma (MM) and must: 1. Have documented disease progression during or after their last myeloma therapy. 2. For Part 1 Dose Finding: Be refractory to, intolerant to, or not a candidate for available, established therapies known to provide clinical benefit in MM; For Part 2 Dose Expansion: Be refractory to or have relapsed after the protocol specified number of prior lines of therapy that include an immunomodulatory drug (IMiD), a proteasome inhibitor, an anti-CD38 mAb, and a T-cell redirecting therapy (TRT, eg, a CAR-T or T-cell enga…
Interventions
- DrugCC-92480
Specified dose on specified days
- DrugTazemetostat
Specified dose on specified days
- DrugBMS-986158
Specified dose on specified days
- DrugTrametinib
Specified dose on specified days
- DrugDexamethasone
Specified dose on specified days
Locations (17)
- UAB Comprehensive Cancer CenterBirmingham, Alabama
- Johns Hopkins Medicine - The Sidney Kimmel Comprehensive Cancer CenterBaltimore, Maryland
- Dana-Farber Cancer InstituteBoston, Massachusetts
- John Theurer Cancer Center at Hackensack UMCHackensack, New Jersey
- Memorial Sloan Kettering Cancer CenterNew York, New York
- Alberta Health Services AHS - Foothills Medical Centre FMCCalgary, Alberta