SV2A Density Cannabis Use Disorder
Yale University
Summary
The main purpose of this study is to determine whether hippocampal synaptic vesicle density estimated by hippocampal \[11C\]APP-311/\[11C\]UCB-J binding in individuals diagnosed with cannabis use disorder (CUDs) improves with at least 4 weeks of confirmed abstinence from cannabis, in comparison to healthy controls (HCs). Furthermore, any change in synaptic vesicle density will be placed in functional context by measuring verbal memory, which is sensitive to hippocampal function, before and after at least 4 weeks of confirmed abstinence. Finally, the relationship between hippocampal \[11C\]UCB-J binding in CUDs with measures of cannabis exposure (e.g., age of initiation, cumulative lifetime dose) will be explored.
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- Yes
CUD Participants Inclusion Criteria: 1. Able to provide informed consent 2. Male and female 18-75 years old 3. Daily cannabis use 4. Positive urine screen for cannabinoids and negative for all other drugs on 5. Diagnosis of DSM-5 cannabis use disorder (≥ moderate, i.e., ≥ 4 \[of 11\] symptoms). 6. Must express a willingness at screening to set a date to attempt to quit using cannabis. 7. Physically healthy i.e., no clinically unstable medical conditions. 8. For women of childbearing potential (WOCBP) and men, willingness to practice birth control and to inform study staff immediately if eithe…
Interventions
- Drug[11C]APP311
For each \[11C\]APP311 (UCB-J) PET scan, up to 20 mCi of \[11C\]APP311 (UCB-J) will be administered by infusion pump. All participants will receive at least two \[11C\]APP311 (UCB-J) PET scans approx. 4 weeks days apart. Approximately 8 CUD participants will be asked to return for a third \[11C\]APP311 (UCB-J) PET scan after an additional 4 weeks following their second scan.
Location
- Yale University School of MedicineNew Haven, Connecticut