Maternal Stress, Human Milk Composition, and Neurodevelopmental and Feeding Outcomes
University of Minnesota
Summary
This study explores the associations between maternal stress, breastmilk composition, and feeding and neurodevelopment for preterm infants in the NICU and at 4 months corrected age.
Description
The proposed study will address our novel hypothesis that maternal stress is associated with feeding outcomes and markers of impaired neurodevelopment for preterm infants and alters human milk and infant gut profiles in ways that affect preterm neurodevelopment. Mothers and their preterm infants (28-34 weeks gestation at birth) will be recruited to determine if: (1) variation in postnatal stress among mothers of very preterm infants relates to the total volume or proportion of maternal milk provided to her infant in the NICU and if (2) variation in maternal postnatal stress relates to her pre…
Eligibility
- Age range
- 0–0 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * preterm infant born between 28 0/7 and 34 6/7 weeks' gestation that are medically stable for study procedures * mother of preterm infant meeting criteria and a) 18 to 45 years of age at the time of delivery Exclusion Criteria: * infants: major congenital anomalies, anticipated death, positive blood culture at birth, hypoxic ischemic encephalopathy, grade IV intraventricular hemorrhage, or plan to transfer care before discharge (35-37 weeks postmenstrual age). * mothers: a) alcohol consumption \>1 drink per week or any tobacco consumption during pregnancy, b) known cong…
Location
- University of MinnesotaMinneapolis, Minnesota